micro block 3

coccobacillus
bordatella and H. influenza
no cysteine
bordatella (all other ella’s are cysteine growth)
filamentum hemaglutanin for adhesion
bordatella
pertussis toxin
bordatella – adp ribosylates ^cAMP
tracheal cytotoxin
bordatella
acute tracheobronchitis (whooping inspiratory cough)
bordatella
undulating fever (waxing and waning)
brucella – granuloma- focal abscess
dermacenter tick bite (from rabbit)
franscisella
ulcerogranuloma lesion (tularaemia ulcer)
franscicella
A/C vents – H2O source
legionella (heavy smoker AND DRINKER)
heavy smoker AND drinker
legionella
atypical pneumonia
CLAMP: chlamydia pneumonia, legionella, mycoplasma, psittaci
ONLY obligate aerobe
pseudomonas
prominent slime layer
pseudomonas
pneumonia in CF kids (blue/green sputum)
pseudomonas
pyoverdin/pyocanin
green and yellow/ green and blue. pseudomonas
elastase, protease invade blood stream. exotoxin a-EEF-2
pseudomonas
hot tub folluculitus, UTI, sepsis, gangrenous, ostenchondritis, ecthyma gangrenosum
pseudomonas
spirochetes
treponema, borrelia burgdorferi, leptospira
Gram – aerobic rods
bordatella, brucella, franscicella, legionalla, pseudomonas
gram – anaerobe
bacteroides
b fragillis
bacteroides (below diaphragm, pt of N flora)
prevotella melaninogenica
bacteroides (above diaphragm)
lung abscesses by aspiration
bacteroides
preoperative cephalosporin for abdominal/pelvic surgery
bacteroides
syphillis
treponema
syphillus stage 1
chancre
dark field microscopy
syphillus stage 2
macular rash, conylomata lata, patchy alopecia
non-specific test – VDRL and RPR
syphillus stage 3
gummas (skin/bone granulomas), CNS (tabes dorsalis) and CVS problems
specific test- FTA. trep as Ag
agglutination w/ cardiolipin
treponema
white foot mouse as reservoir
borrelia burgdorferi

Lymes

ixodes pacificus
borrelia burgdorferi WEST vector
ixodes scapularis
borrelia burgdorferi EAST vector
borrelia burgdorferi vectors
west = ixodes pacificus
east = ixodes scapularis
lymes
borrelia burgdorferi
lymes stage 1
erythrema chronicum – “bulls eye rash”. painless
lymes stage 2
heart block and bells balsy
lymes stage 3
large joint arthitis
water sports
leptospira – animal urine contaminates water
facultative anaerobes
pasteurella, H. influenza, vibrio, campylobacter, H. pylori
cat or dog bites
pasteurella
type B polyribotol capsule
H. influenza – unencapsulated strains are untypeable
epiglottitis
h. influenza
comma shaped
vibrio cholera
seagull shaped
campylobacter
microaerophillic
campylobacter
42% growth
campylobacter
enterocolitis
campylobacter, salmonella, shigella, yersinia
ferment glu, oxidase -, cat +, nitrates -> nitrites
enterobacteria -CEEK SHYPS
rice water diarrhea
vibrio cholera
mucinase
vibrio cholera and h. pylori
urease +
h. pylori, proteus
difference between vibrio cholera and parahaemolyticus
cholera doesn’t grow in 8% NaCl
MASSIVE water loss
vibrio cholera
cholera toxins:
mucinase, choleragen toxin – ADP- R ^cAMP
vibrio parahaemolyticus
raw seafood, cholera like toxin
cellulitis for shellfish handlers
vibrio vulnificus
e coli toxins:
O, H, K Ag, enterotoxins (heat stabile and heat labile), K1 has a capsule
O ag
serotying, cell wall
H Ag
motility (Hairy flagella)
K Ag
Capsule (Kapsule)
ETEC
travelers diarrhea, heat labile toxin (^CAMP) and heat stabile toxin (^CGMP)
EPEC
pediatrics diarrhea, disrupts microvilli
EIEC
invasive, inflammatory = blood and pus = dysentary
EHEC
hemorrhagic- blood but no pus, hamburgers and petting zoos, HUS 0157:H7
hamburgers and petting zoos
EHEC
HUS
EHEC complication
ART- anemia, renal failure, thrombocytopenia
phe deaminase +
proteus
swarming motility
proteus
glistening mucoid colonies
kliebshiella capsule
“red currant jelly sputum”
kliebshiella
O ag, Vi ag
salmonella
non lactose fermenting
SHYPS- shigella, yersinia – non motile, non H2S
-proteus, salmonella – motile, H2S producing
lactose fermenting
CEEK- campylobacter, enterobacter, e. coli, kliebshiella
pink colonies on macconkeys
lactose fermenters- CEEK
typhi
salmonella- typhoid fever- peyer patches. GB = carrier state
paratyphi
salmonella. enteric fever
choleraesius
Salmonella. septicemia, osteomyelitis in sickle cell
enteriditis
salmonella. enterocolitis
HIGH infective dose (>100,000)
salmonella
shiga toxin
nicks 60 s ribo subunit (shigella)
dysentary
shigella (does nothing but shit) bloody diarrhea W/ PUS

And EHEC

daycare and mental ward
shigella
predisposed to Reiter syndrome
shigella
bubonic and pneumonic plague
yersinia
chocolate agar w/ factors X and V
H. influenza

(X and no V = ducreye)

high infective dose (>100,000)
salmonella
low infective dose (~100)
shigella

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